Allamah Majlisi says that I have read in some books, that when Imam Hussein (A.S) decided to leave Medina, Ummu-Salamah came to him and said, "O my dear son! Do not aggrieve me by going towards Iraq. For I have heard your Grandfather say that my son Hussein will be killed in Iraq at a place called Karbala." Imam replied:
"O dear Grandmother! I too am aware of it and I shall be forcefully killed while there is no escape from it. By Allah! I know the day when I shall be killed and recognize my murderer besides being aware of the Mausoleum where I shall be buried. And I know all those people among my family, relatives and followers who shall die along with me. Then Imam said:
"O Grandmother! Allah Almighty desires to see me killed and that my head be severed with cruelty and injustice. Besides (Allah) desires that my family and womenfolk be expelled, and my children oppressed, bare headed, arrested and bound in chains. And they would plead and call out for help, but none would come to their aid."
In another tradition it is stated that the holy Prophet (PBUH) gave some sand to Ummu-Salamah and said: when it turns into blood know that my beloved Hussein has been martyred.
source : tebyan