The word "Ghadir" is of several meanings in terminology, such as "pond", "a piece of water," and "rain water".
Ghadir Khom is located in the middle of the two great cities of the Muslim world, Mecca and Medina, in the place called "Ja'fah"; and at the time of the messenger of Islam (peace be upon him and his progeny), the Hajj caravans separated there and went toward their own country. There are several possibilities on why this place is named Ghadir Khom; for example one reason can be the weather of this place.
Having been ordered by Almighty Allah, the Prophet of Islam peace be upon him and his progeny appointed Imam Ali ibn Abi Talib (AS) as a leader and successor in Ghadir Khom.
source : erfan.ir